Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma

Atypical non-[99mTc]Tc-MIBI avid parathyroid adenoma with a sternal brown tumor, mimicking ectopic parathyroid adenoma in planar and SPECT images: Importance of SPECT/CT acquisition

Primary hyperparathyroidism (pHPT) is defined by the excess level of parathyroid hormone (PTH). Parathyroid adenoma is responsible for about 80% of all pHPT. Parathyroid adenoma with cystic feature and atypical pathology is recognized as a rare entity. Technetium-99m methoxy isobutyl isonitrile ([99mTc]Tc-MIBI) scintigraphy has favorable detection rate for ectopic gland as well as th...

Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?

BACKGROUND Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical parathyroid adenomas, but distinguishing them from each other is more difficult. METHODS A retrospective study of 28 consecutive patients with parathyroid carcinoma, 7 patients with atypical parathyroid adenoma, and 13 patients with parathyromatosis who wer...

Significance of MIBI scintigraphy in a patient with hydatid cyst and parathyroid adenoma

A 17-year-old boy with hyperparathyroidism exhibited a large cyst in the left hemi-thorax on his chest X-ray. The cyst was identified as a hydatid cyst. He was referred for biphasic methoxy isobutyl isonitrile (MIBI) parathyroid scan. A discrete ectopic parathyroid was detected in the left upper mediastinum in addition to accumulation of the MIBI tracer in the cyst wall. Using radio-guided occu...

Her Aching Bones: Atypical Parathyroid Adenoma.

Atypical parathyroid adenoma with diffuse fibrosis.

Parathyroid adenomas are benign encapsulated neoplasms that are typically comprised of chief cells and feature a rim of normal parathyroid tissue at their periphery. A small subset can be classified as atypical based on the presence of some histologic features of malignancy, such as a trabecular growth pattern, increased mitotic activity, capsular invasion, and fibrous bands, without definitive...